(5′S) 5′,8-cyclo-2′-deoxyadenosine Cannot Stop BER. Clustered DNA Lesion Studies
نویسندگان
چکیده
منابع مشابه
Formation of 5',8-cyclo-2'-deoxyadenosine in single strand DNA. Theoretical quantum mechanics study.
Reactions of reactive oxygen species, and more specifically, of hydroxyl radicals, with nucleotides, may lead to the generation of radicals in the base and the 2-deoxyribose moieties of DNA. In the present study, for the first time, emphasis was placed on the investigation of the possible reaction of 2'-deoxyadenosine-3',5'-diphosphate radicals, leading to the formation of the related 5',8-cycl...
متن کاملA 5′, 8-cyclo-2′-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β
5',8-cyclo-2'-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation. The lesions can only be repaired by nucleotide excision repair with a low efficiency. This results in their accumulation in the genome that leads to stalling of the replication DNA polymerases and poor lesion bypass by translesion D...
متن کاملRegular paper 5’,8-Cyclo-2’-deoxyadenosine (cdA) formation by γ-radiation. Theoretical quantum mechanics study
Reactions of reactive oxygen species and more specifically — of hydroxyl radical (•OH) — with nucleosides may lead to the generation of radicals in the base and 2-deoxyribose moieties. In the present study emphasis was put on the possible reaction modes of 2'-deoxyadenosine (dA) radicals, leading to the formation of related 5’,8-cyclonucleosides. It appears that the prerequisite for the formati...
متن کاملRepair efficiency of (5'S)-8,5'-cyclo-2'-deoxyguanosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine depends on the complementary base.
5'-R and 5'-S diastereoisomers of 8,5'-cyclo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine (cdG) containing a base-sugar covalent bond are formed by hydroxyl radicals. R-cdA and S-cdA are repaired by nucleotide excision repair (NER) in mammalian cellular extracts. Here, we have examined seven purified base excision repair enzymes for their ability to repair S-cdG or S-cdA. We could n...
متن کاملClustered DNA Lesions Containing 5-Formyluracil and AP Site: Repair via the BER System
Lesions in the DNA arise under ionizing irradiation conditions or various chemical oxidants as a single damage or as part of a multiply damaged site within 1-2 helical turns (clustered lesion). Here, we explored the repair opportunity of the apurinic/apyrimidinic site (AP site) composed of the clustered lesion with 5-formyluracil (5-foU) by the base excision repair (BER) proteins. We found, tha...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22115934